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A new Omicron lineage with Spike Y451H mutation that dominated a new COVID-19 wave in Kilifi, Coastal Kenya: March-May 2023

Mwanga, M. J.; LAMBISIA, A. W.; Morobe, J. M.; Murunga, N.; Moraa, E.; Ndwiga, L.; Robinson, C.; Mutunga, M.; Guzman Rincon, L. M.; Sande, C.; Mwangangi, J.; Bejon, P.; Ochola-Oyier, l. I.; Nokes, J.; Agoti, C. N.; Nyiro, J.; Githinji, G.

2023-07-03 infectious diseases
10.1101/2023.07.03.23292158 medRxiv
Show abstract

We report a newly emerged SARS-CoV-2 Omicron lineage, named FY.4, that has two unique mutations; spike:Y451H and ORF3a:P42L. FY.4 emergence has coincided with increased SARS-CoV-2 cases in coastal Kenya, April-May 2023. We demonstrate the value of continued SARS-CoV-2 genomic surveillance in the post-acute pandemic era in understanding new COVID-19 outbreaks.

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