Immunologically mediated trade-offs shaping transmission of sylvatic dengue and Zika viruses in native and novel non-human primate hosts
Hanley, K. A.; Cecilia, H.; Azar, S. R.; Moehn, B.; Yu, W.; Yun, R.; Althouse, B. M.; Vasilakis, N.; Rossi, S. L.
Show abstract
Mosquito-borne dengue (DENV) and Zika (ZIKV) viruses originated in Old World sylvatic cycles involving monkey hosts, spilled over into human transmission, and were translocated to the Americas, creating potential for spillback into neotropical sylvatic cycles. Studies of the trade-offs that shape within-host dynamics and transmission of these viruses are lacking, hampering efforts to predict spillover and spillback. We exposed native (cynomolgus macaque) or novel (squirrel monkey) hosts to mosquitoes infected with either sylvatic DENV or ZIKV and monitored viremia, natural killer cells, transmission to mosquitoes, cytokines, and neutralizing antibody titers. Unexpectedly, DENV transmission from both host species occurred only when serum viremia was undetectable or near the limit of detection. ZIKV replicated in squirrel monkeys to much higher titers than DENV and was transmitted more efficiently but stimulated lower neutralizing antibody titers. Increasing ZIKV viremia led to greater instantaneous transmission and shorter duration of infection, consistent with a replication-clearance trade-off.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage 97%
- Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes 96%
- The association of neutralizing antibodies with protection against symptomatic dengue virus infection varies by serotype, prior infection history, and assay condition 95%
Similar papers in this journal
- Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus 96%
- In depth sequencing of a serially sampled household cohort reveals the within-host dynamics of Omicron SARS-CoV-2 and rare selection of novel spike variants 94%
- Viral RNA is a target for Wolbachia-mediated pathogen blocking 94%
Similar papers in this journal
- Prevention and Treatment of SHIVAD8 Infection in Rhesus Macaques by a Potent D-peptide HIV Entry Inhibitor 95%
- Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants 94%
- Mechanistic Insights into Dengue Virus Inhibition by a Clinical Trial Compound NITD-688 94%
Similar papers in this journal
- Rapid evolution of enhanced Zika virus virulence during direct vertebrate transmission chains 96%
- A Tetravalent Dengue Virus-like Particle Vaccine Induces High levels of Neutralizing Antibodies and Inhibits Dengue Replication in Non-Human Primates 95%
- Deep mutational scanning comprehensively maps how Zika envelope protein mutations affect viral growth and antibody escape 95%
Similar papers in this journal
- Repeated introductions and intensive community transmission fueled a mumps virus outbreak in Washington State 94%
- Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay 94%
- Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: a retrospective cohort study 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.