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Ethnicity is not biology: retinal pigment score to evaluate biological variability from ophthalmic imaging using machine learning
2023-07-06
ophthalmology
Title + abstract only
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BackgroundFew metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as an inappropriate marker for biological variability. MethodsWe derived a continuous, measured metric, the retinal pigment score (RPS), that quantifies the degree of pigmentation from a colour fundus photograph of the eye. RPS was validated using two large epidemiological studies with demographic and genetic data (UK Biobank and EPIC-Norfolk Study). FindingsA...
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