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Association of Nirmatrelvir/Ritonavir treatment and COVID-19 neutralizing antibody titers in a longitudinal healthcare worker cohort

Decker, S.; Xiao, S.; Dillen, C.; Schumacher, C.; Milstone, A. M.; Frieman, M.; Debes, A. K.

2023-06-20 infectious diseases
10.1101/2023.06.19.23291620 medRxiv
Show abstract

Nirmatrelvir/Ritonavir (NMV/r) is used for the treatment of COVID-19 infection. However, rebound COVID-19 infections can occur after taking NMV/r. We examined neutralizing antibodies to the SARS-CoV-2 spike protein before and after infection in people who did and did not take NMV/r to determine if NMV/r impedes the humoral immune response.

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