Back
Top 2%
21.5%
Top 29%
7.5%
Top 4%
5.8%
Top 2%
5.8%
Top 1%
5.8%
Top 8%
4.9%
Top 4%
4.9%
#1
4.9%
Top 0.3%
3.7%
Top 90%
2.7%
Top 3%
1.9%
Top 0.6%
1.5%
Top 5%
1.5%
Top 5%
1.5%
Top 6%
1.5%
Top 5%
1.3%
Top 6%
1.1%
Top 11%
1.1%
Top 6%
1.1%
Top 2%
0.9%
Top 4%
0.9%
Top 6%
0.9%
Top 11%
0.9%
Top 2%
0.9%
Top 6%
0.7%
Top 6%
0.7%
Top 6%
0.7%
Top 5%
0.7%
Top 8%
0.7%
Tracing the evolutionary path of the CCR5delta32 deletion via ancient and modern genomes
2023-06-20
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
The chemokine receptor variant CCR5delta32 is linked to HIV-1 infection resistance and other pathological conditions. In European populations, the allele frequency ranges from 10-16%, and its evolution has been extensively debated throughout the years. We provide a detailed perspective of the evolutionary history of the deletion through time and space. We discovered that the CCR5delta32 allele arose on a pre-existing haplotype consisting of 84 variants. Using this information, we developed a hap...
Predicted journal destinations
1
Nature Communications
483 training papers
2
Scientific Reports
701 training papers
3
The American Journal of Human Genetics
77 training papers
4
Genome Medicine
56 training papers
5
Proceedings of the National Academy of Sciences
100 training papers
6
eLife
262 training papers
7
Nature Genetics
72 training papers
8
Virus Evolution
26 training papers
9
Nature
58 training papers
10
PLOS ONE
1737 training papers
11
Cell Genomics
34 training papers
12
PLOS Pathogens
35 training papers
13
Nature Medicine
88 training papers
14
Human Genetics and Genomics Advances
39 training papers
15
Genetics in Medicine
57 training papers
16
Human Molecular Genetics
28 training papers
17
Frontiers in Genetics
32 training papers
18
PLOS Computational Biology
141 training papers
19
PLOS Genetics
39 training papers
20
Bioinformatics
24 training papers
21
Genes
21 training papers
22
European Journal of Human Genetics
25 training papers
23
iScience
74 training papers
24
Cell
28 training papers
25
Communications Biology
36 training papers
26
Journal of The Royal Society Interface
54 training papers
27
Science Advances
52 training papers
28
Science Translational Medicine
40 training papers
29
Science
46 training papers