Functional Sexual Dimorphism in Human Nociceptors
Stratton, H. J.; Dolatyari, M.; Dumaire, N.; Moutal, A.; Ghetti, A.; Cotta, T.; Mitchell, S.; Yue, X.; Navratilova, E.; Porreca, F.
10.1101/2023.06.14.545010 bioRxivShow abstract
The recent demonstration of differences in transcript expression in human post-mortem sensory neurons suggests the possibility of sexually dimorphic pain mechanisms. To date, however, the concept of "male" and "female" nociceptors has not been demonstrated at a functional level. We now report sensitization of female, but not male, human nociceptors by prolactin revealing a female-selective mechanism that can be exploited to improve the treatment of pain in women.
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