Admission biomarkers may not have an association with cardiovascular involvement in Latin American patients with Multisystem Inflammatory Syndrome in Children (MIS-C)

ObjectivesThe aim of the study is to determine if there is an association between altered biomarkers and cardiovascular involvement in Latin American patients with MIS-C. DesignThe researchers of this study conducted a retrospective cohort study. SettingSecondary care maternal unit hospital in Monterrey, NL, Mexico. ParticipantsAny register of a Latin-American pediatric patient with MIS-C within the database from March 2019 to February 2022. Primary and secondary outcome measuresCut, mean, odds ratio (OR), relative ratio (RR), 95% confidence interval (CI) and p values of inflammatory markers associated with cardiovascular affection in MIS-C. As a secondary outcome we measure being male as an independent risk factor. ResultsNone of the biomarkers and gender variables taken were significant (Table 1). O_TBL View this table: org.highwire.dtl.DTLVardef@1140c78org.highwire.dtl.DTLVardef@13eb581org.highwire.dtl.DTLVardef@1fe447corg.highwire.dtl.DTLVardef@426569org.highwire.dtl.DTLVardef@10fd4bb_HPS_FORMAT_FIGEXP M_TBL O_FLOATNOTable 1.C_FLOATNO C_TBL ConclusionsThe researchers analysis suggests there is no evidence of cause-effect association between admission biomarkers and the presence of cardiovascular affection in MIS-C. Remarkably, neutrophilia and ESR had a high odds ratio and a nearly significant p-value, which makes them ideal for further analysis with a bigger sample. Additionally, gender was included as a risk factor and was analyzed independently, nonetheless, it was not associated with a higher risk of presenting cardiovascular affection. Article summary Strengths and limitations of this studyO_LIFirst study measuring the association of a series of available and economical biomarkers with a higher incidence of cardiovascular involvement in MIS-C in a Latin-American population. C_LIO_LISet ground for further research regarding the current treatment of MIS-C C_LIO_LISample size non-representative. C_LIO_LISince this is an observational study we cant fully control confounding and bias (e.j. reporting bias) C_LI