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Chitin degradation by Synechococcus WH7803

Capovilla, G.; Castro, K. G.; Collani, S.; Kearney, S. M.; Kehoe, D. M.; Chisholm, S. W.

2023-06-07 microbiology
10.1101/2023.06.07.544114 bioRxiv
Show abstract

Chitin is an abundant, carbon-rich polymer in the marine environment. Chitinase activity has been detected in spent media of Synechococcus WH7803 cultures - yet it was unclear which specific enzymes were involved. Here we delivered a CRISPR tool into the cells via electroporation to generate loss-of-function mutants of putative candidates and identified ChiA as the enzyme required for the activity detected in the wild type.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.