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A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

Chang, H.; Feng, S.; Tang, X.; Wang, Z.; Su, W.; Han, S.; Li, G.; Hu, B.; Jing, S.; Wang, B.; Xiang, C.; Xing, Y.; Wang, Y.; Lu, J.; He, h.

2023-06-05 microbiology
10.1101/2023.06.05.543675 bioRxiv
Show abstract

PPMV-1, an antigenic variant of APMV-1, associated with specific pigeon host species. However, its evolutionary strategy and underlying drivers of host specificity remain unknown. In this study, we collect the outbreak data on a global scale to investigate its evolutionary dynamics, and provide an evidence-supported analysis the host shift of PPMV-1 from chickens to pigeons, and this shift is driven by the P protein. Our data indicated that the viruses in the United States and China have undergone convergent evolution. We find that three mutations of P protein, especially R163G, can significantly affect the adaptation of APMV-1 in pigeons. Mechanistically, sensor LSm14A inhibits the replication APMV-1 in DF-1 cells, and R163G substitutionon P protein increase LSm14A degradation. We propose the host shift drive the evolution of PPMV-1 and the underlying mechanism, offering new insights into the adaptive evolutionary process of the virus.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.