Depression events associated with proton-pump inhibitors in postmarketing drug surveillance data

2023-06-05 pharmacology and therapeutics Title + abstract only

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Proton-pump inhibitors, PPIs, are widely prescribed and are available over the counter for prolonged reduction of stomach acid production and related disorders. PPIs irreversibly inhibit the hydrogen/potassium ATPase in gastric parietal cells. Recent retrospective studies have described an association between PPI use and depression. However, there is conflicting evidence that PPI therapy improves depressive symptoms. Considering the widespread use and over the counter availability of these drugs...

Depression events associated with proton-pump inhibitors in postmarketing drug surveillance data

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