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Formation of amyloid fibrils by the regulatory 14-3-3ζ protein

Sulskis, D.; Ziaunys, M.; Sakalauskas, A.; Smirnovas, V.

2023-06-02 biochemistry
10.1101/2023.05.31.543065 bioRxiv
Show abstract

The 14-3-3 is a highly conserved adaptor protein family with multi-layer functions, abundantly expressed in the brain. The 14-3-3 proteins modulate phosphorylation, regulate enzymatic activity and can act as chaperones. Most importantly, they play an important role in various neurodegenerative disorders due to their vast interaction partners. Particularly, the 14-3-3{xi} isoform is known to co-localize in aggregation tangles in both Alzheimers and Parkinsons diseases as a result of protein-protein interactions. These abnormal clumps consist of amyloid fibrils - insoluble aggregates, mainly formed by amyloid-{beta}, tau and -synuclein proteins. However, the molecular basis of if and how 14-3-3{xi} can aggregate into amyloid fibrils is unknown. In this study, we describe the formation of amyloid fibrils by 14-3-3{xi} utilizing a comprehensive approach that combines bioinformatic tools, amyloid-specific dye binding, secondary structure analysis and atomic force microscopy. The results presented herein characterize the amyloidogenic properties of 14-3-3{xi} and imply that the well-folded protein undergoes aggregation to {beta}-sheet-rich amyloid fibrils.

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