A pancreatic cancer mouse model with human immunity
Miyamura, N.; Suzuki, K.; Friedman, R. A.; Floratos, A.; Kunisada, Y.; Masuda, K.; Lowy, A. M.; Tsuji, M.; Sugahara, K. N.
Show abstract
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a tumor immune microenvironment (TIME) that promotes resistance to immunotherapy. A preclinical model system that facilitates studies of the TIME and its impact on the responsiveness of human PDAC to immunotherapies remains an unmet need. We report a novel mouse model, which develops metastatic human PDAC that becomes infiltrated by human immune cells recapitulating the TIME of human PDAC. The model may serve as a versatile platform to study the nature of human PDAC TIME and its response to various treatments.
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