Dichotomy of neutralizing antibody, B cell and T cell responses to SARS-CoV-2 vaccination and protection in healthy adults
Carr, E. J.; Townsley, H.; Wu, M. Y.; Wilkinson, K. A.; Hobson, P. S.; Levi, D.; Namjou, S.; Mears, H. V.; Hobbs, A.; Ragno, M.; Herman, L. S.; Harvey, R.; Bailey, C.; Fowler, A. S.; Hatipoglu, E.; Ngai, Y.; Clayton, B.; Miah, M.; Bawumia, P.; Miranda, M.; Smith, C.; Sawyer, C.; Kelly, G.; Mahalingasivam, V.; Zheng, B.; Evans, S. J.; Libri, V.; Riddell, A.; Nicod, J.; O'Reilly, N.; Howell, M.; Williams, B.; Wilkinson, R. J.; Kassiotis, G.; Swanton, C.; Gandhi, S.; Beale, R. C.; Bauer, D. L.; Wall, E. C.
Show abstract
Heterogeneity in SARS-CoV-2 vaccine responses is not understood. Here, we identify four patterns of live-virus neutralizing antibody responses: individuals with hybrid immunity (with confirmed prior infection); rare individuals with low responses (paucity of S1-binding antibodies); and surprisingly, two further groups with distinct serological repertoires. One group - broad responders - neutralize a range of SARS-CoV-2 variants, whereas the other - narrow responders - neutralize fewer, less divergent variants. This heterogeneity does not correlate with Ancestral S1-binding antibody, rather the quality of the serological response. Furthermore, IgDlowCD27-CD137+ B cells and CCR6+ CD4+ T cells are enriched in broad responders before dose 3. Notably, broad responders have significantly longer infection-free time after their third dose. Understanding the control and persistence of these serological profiles could allow personalized approaches to enhance serological breadth after vaccination.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity in uninfected and previously infected individuals 98%
- SARS-CoV-2 B.1.1.7 escape from mRNA vaccine-elicited neutralizing antibodies 97%
- High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study 96%
Similar papers in this journal
- The hyper-transmissible SARS-CoV-2 Omicron variant exhibits significant antigenic change, vaccine escape and a switch in cell entry mechanism 97%
- Antibody longevity and cross-neutralizing activity following SARS-CoV-2 wave 1 and B.1.1.7 infections 96%
- Viral evolution prediction identifies broadly neutralizing antibodies against existing and prospective SARS-CoV-2 variants 96%
Similar papers in this journal
- Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains 96%
- Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein after infection and/or vaccination 96%
- ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.