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Multi-organ genetic causal connections inferred from imaging and clinical data through Mendelian randomization

2023-05-28 genetic and genomic medicine Title + abstract only
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Understanding the complex causal relationships among major clinical outcomes and the causal interplay among multiple organs remains a significant challenge. By using imaging phenotypes, we can characterize the functional and structural architecture of major human organs. Mendelian randomization (MR) provides a valuable framework for inferring causality by leveraging genetic variants as instrumental variables. In this study, we conducted a systematic multi-organ MR analysis involving 402 imaging ...

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