Telocytes are a critical source of Wnts essential for hair follicle regeneration
Canella, M.; Nalick, S.; Corem, N.; Gharbi, A.; Ben-Porath, I.; Shoshkes Carmel, M.
Show abstract
Self-renewing tissues rely on stem cells (SCs) to regenerate differentiated cells, requiring precise coordination between SCs and their progeny. Here, we investigated how SC activity is regulated across multiple epithelial layers, using the hair follicle (HF) as a model system. We uncovered an extensive, interconnected network of telocytes, specialized mesenchymal cells, that spans all HF layers, including regions previously thought to lack mesenchymal or connective tissue components. These telocyte networks remain in constant contact with SCs and their progeny throughout regeneration, dynamically adapting their structure and molecular profile to provide localized, phase-specific signals. By employing two independent mouse models to ablate telocytes or disrupt their Wnt signaling, we demonstrate that telocyte networks are an essential component of the SC niche. Our findings propose a revised, integrative model of the SC niche, in which telocyte networks and their Wnt production play a central role in adult SC biology and tissue regeneration.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line 93%
- Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin 92%
- Mapping the developmental potential of mouse inner ear organoids at single-cell resolution 92%
Similar papers in this journal
- LIN28B controls the regenerative capacity of neonatal murine auditory supporting cells through activation of mTOR signaling 93%
- ISL1 is necessary for auditory neuron development and contributes towards tonotopic organization 92%
- Phased ERK-responsiveness and developmental robustness regulate teleost skin morphogenesis 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.