Phase transition of maternal RNAs during vertebrate oocyte-to-embryo transition
Hwang, H.; Chen, S.; Ma, M.; Divyanshi, ; Fan, H.-C.; Borwick, E.; Böke, E.; Mei, W.; Yang, J.
Show abstract
The oocyte-to-embryo transition (OET) is regulated by maternal products stored in the oocyte cytoplasm, independent of transcription. How maternal products are precisely remodeled to dictate the OET remains an open question. In this work, we discover the dynamic phase transition of maternal RNAs during Xenopus OET. We have identified 863 maternal transcripts that transition from a soluble state to a detergent-insoluble one after oocyte maturation. These RNAs are enriched in the animal hemisphere and many of them encode key cell cycle regulators. In contrast, 165 transcripts, including nearly all Xenopus germline RNAs and some vegetally localized somatic RNAs, undergo an insoluble-to-soluble phase transition. This phenomenon is conserved in zebrafish. Our results demonstrate that the phase transition of germline RNAs influences their susceptibility to RNA degradation machinery and is mediated by the remodeling of germ plasm. This work thus uncovers novel remodeling mechanisms that act on RNAs to regulate vertebrate OET.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- TAF4b transcription networks regulating early oocyte differentiation 94%
- Collective nuclear behavior shapes bilateral nuclear symmetry for subsequent left-right asymmetric morphogenesis in Drosophila 93%
- Caenorhabditis elegans germ granules are present in distinct configurations that differentially associate with RNAi-targeted RNAs 93%
Similar papers in this journal
- Sex-specific transcript diversity is regulated by a maternal pioneer factor in early Drosophila embryos 95%
- Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis 95%
- Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition 94%
Similar papers in this journal
- Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression 94%
- Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis 94%
- Integrated Stress Response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.