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Serialized On-grid Lift-In Sectioning for Tomography (SOLIST)

Erdmann, P. S.; Nguyen, T.-D. H.; Perone, G.; Vazzana, R.; Don, F. K.; Silva, M.; Sorrentino, S.; Swuec, P.; Leroux, F.; Kalebic, N.; Coscia, F.

2023-05-14 biophysics
10.1101/2023.05.11.540146 bioRxiv
Show abstract

Cryo-focused ion beam milling has enabled groundbreaking structural discoveries in native cells. Progress toward medically relevant applications, however, has been slow. We here present an adaptation of the cryo-lift out procedure for Serialized On-grid Lift-In Sectioning for Tomography (SOLIST), which increases throughput, reduces ice contamination, and enhances sample stability. With these improvements, new specimens, ranging from high-pressure frozen reconstituted LLPS droplets to human forebrain organoids, are accessible to cryo-electron tomography.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.