Mild/Asymptomatic Maternal SARS-CoV-2 Infection Leads to Immune Paralysis in Fetal Circulation and Immune Dysregulation in Fetal-Placental Tissues
Doratt, B. M.; Sureshchandra, S.; True, H.; Rincon, M.; Marshall, N. E.; Messaoudi, I.
Show abstract
Few studies have addressed the impact of maternal mild/asymptomatic SARS-CoV-2 infection on the developing neonatal immune system. In this study, we analyzed umbilical cord blood and placental chorionic villi from newborns of unvaccinated mothers with mild/asymptomatic SARS-CoV-2 infection during pregnancy using flow cytometry, single-cell transcriptomics, and functional assays. Despite the lack of vertical transmission, levels of inflammatory mediators were altered in cord blood. Maternal infection was also associated with increased memory T, B cells, and non-classical monocytes as well as increased activation. However, ex vivo responses to stimulation were attenuated. Finally, within the placental villi, we report an expansion of fetal Hofbauer cells and infiltrating maternal macrophages and rewiring towards a heightened inflammatory state. In contrast to cord blood monocytes, placental myeloid cells were primed for heightened antiviral responses. Taken together, this study highlights dysregulated fetal immune cell responses in response to mild maternal SARS-CoV-2 infection during pregnancy.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Transplacental innate immune training via maternal microbial exposure: a central role for the XBP1-ERN1 axis in programming dendritic cell precursors 96%
- Systemic immune dysregulation in hypertensive disorders of pregnancy persists years after delivery 94%
- Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years. 94%
Similar papers in this journal
- Balance between maternal antiviral response and placental transfer of protection in gestational SARS-CoV-2 infection 95%
- Human regulatory T cells at the maternal-fetal interface show functional site-specific adaptation with tumor-infiltrating-like features 94%
- Perturbation of the Preterm Human Immune System in Early Life 94%
Similar papers in this journal
- Impact of pregravid obesity on anti-microbial fetal monocyte response 95%
- Single Cell Transcriptional Signatures of the Human Placenta in Term and Preterm Parturition 95%
- Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface 94%
Similar papers in this journal
- Functional and genomic adaptations of blood monocytes to pregravid obesity during pregnancy 94%
- Factor V is an immune inhibitor that is expressed at increased levels in leukocytes of patients with severe Covid-19 94%
- Maternal obesity and offspring neurodevelopment are associated with hypoxic gene expression in term human placenta 93%
Similar papers in this journal
- Stereotypic expansion of Tregulatory and Th17 cells during infancy is disrupted by HIV exposure and gut epithelial damage. 94%
- Single-cell analysis reveals the range of transcriptional states of circulating human neutrophils 94%
- Single-cell profiling of blood and cerebrospinal fluid in tuberculous meningitis 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.