A cortisol-driven gene expression signature from circulating monocytes and neutrophils during severe inflammation

2023-05-11 allergy and immunology Title + abstract only

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Glucocorticoids (GCs) are used as anti-inflammatory and immunosuppressive drugs in many immune mediated diseases, but their use in sepsis and shock is controversial. This is caused in part by a lack of information regarding the responding cell types and GC-regulated genes in vivo. We used public blood transcriptomic datasets and GC-induced query genes to obtain 2 robust gene expression correlation signatures of GC induction, either in the absence or in the presence of severe inflammation. GC sig...

A cortisol-driven gene expression signature from circulating monocytes and neutrophils during severe inflammation

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