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Antigenic responses are hallmarks of fibrotic interstitial lung diseases independent of underlying etiologies.
2023-05-11
respiratory medicine
Title + abstract only
View on medRxiv
Show abstract
Interstitial lung diseases (ILD) are heterogeneous conditions that may lead to progressive fibrosis and death of affected individuals. Despite diversity in clinical manifestations, enlargement of lung-associated lymph nodes (LLN) in fibrotic ILD patients predicts worse survival. Herein, we revealed a common adaptive immune landscape in LLNs of all ILD patients, characterized by highly activated germinal centers and antigen-activated T cells including regulatory T cells (Tregs). In support of the...
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