K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ)
Garadi Suresh, H.; Bonneil, E.; Albert, B.; Dominique, C.; Costanzo, M.; Pons, C.; Masinas, M. P. D.; Shuteriqi, E.; Shore, D.; Henras, A. K.; Thibault, P.; Boone, C.; Andrews, B. J.
Show abstract
Ribosome assembly requires precise coordination between the production and assembly of ribosomal components. Mutations in ribosomal proteins that inhibit the assembly process or ribosome function are often associated with Ribosomopathies, some of which are linked to defects in proteostasis. In this study, we examine the interplay between several yeast proteostasis enzymes, including deubiquitylases (DUBs), Ubp2 and Ubp14, and E3 ligases, Ufd4 and Hul5, and we explore their roles in the regulation of the cellular levels of K29-linked unanchored polyubiquitin (polyUb) chains. Accumulating K29-linked unanchored polyUb chains associate with maturing ribosomes to disrupt their assembly, activate the Ribosome assembly stress response (RASTR), and lead to the sequestration of ribosomal proteins at the Intranuclear Quality control compartment (INQ). These findings reveal the physiological relevance of INQ and provide insights into mechanisms of cellular toxicity associated with Ribosomopathies.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- AMPK regulates ESCRT-dependent microautophagy of proteasomes concomitant with proteasome storage granule assembly during glucose starvation 97%
- 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity 96%
- The kinase Isr1 negatively regulates hexosamine biosynthesis in S. cerevisiae 95%
Similar papers in this journal
- Chaperone Complexes From The Endoplasmic Reticulum (ER) And The Cytosol Inhibit wt-p53 By Activation The ER To Cytosol Signaling. 93%
- The Lon protease temporally restricts polar cell differentiation events during the Caulobacter cell cycle 93%
- Therapeutic genetic variation revealed in diverse Hsp104 homologs 93%
Similar papers in this journal
- ECPAS/Ecm29-Mediated 26S Proteasome Disassembly Is an Adaptive Response to Glucose Starvation 94%
- Nα-terminal acetylation of proteins by NatA and NatB serves distinct physiological roles in Saccharomyces cerevisiae 94%
- The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins 93%
Similar papers in this journal
- Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion 95%
- Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor 92%
- Sensitive detection of protein ubiquitylation using a protein-fragment complementation assay 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.