Gut microbiota and maternal immune transfer at birth influence pre-allergic clinical outcome.
Villette, R.; Traore, D.; Dhilly, E.; Foucault, P.; Parisel, E.; Sauce, D.; Gorochov, G.; Kayem, G.; Schuhmacher, M.; Annesi-Maesano, I.; Larsen, M.; EarlyFOOD study group,
Show abstract
The gut microbiota of 2-3 month-old infants is associated with later pre-allergic signs, while the microbiota at the time of allergic manifestation is not. We hypothesized that the infant gut microbiota and immune system are primed shortly after birth, and that this is influenced by maternal transfer of humoral immunity. We investigated the association between allergic outcomes and composition and humoral immunity to gut microbiota at birth, 2 months, and 2 years-of-age. Meconium microbiota clustered into three groups dominated by Escherichia, Enterococcus, and mixed genera, respectively. The Escherichia cluster was associated with protection against later allergic manifestations. We moreover studied the proportion and specificity of humoral immunity to gut microbiota. Humoral immunity to gut microbiota at birth was associated with future allergies. Future studies should evaluate whether interventions to alter gut microbiota and humoral immunity in early-life protects against allergy.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants 95%
- Mechanical ventilation affects respiratory microbiome of COVID-19 patients and its interactions with the host 95%
- Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut 95%
Similar papers in this journal
- Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy 95%
- Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease 95%
- The influence of early life exposures on the infant gut virome 95%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Microbial succession at weaning is guided by microbial metabolism of host glycans. 95%
- Colonization during a key developmental window reveals microbiota-dependent shifts in growth and immunity during undernutrition 95%
- Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.