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Investigating causal relationship between smoking behavior and global brain volume

2023-04-28 addiction medicine Title + abstract only
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BackgroundPrevious studies have shown that brain volume is negatively associated with cigarette smoking, but there is an ongoing debate whether smoking causes lowered brain volume or a lower brain volume is a risk factor for smoking. We address this debate through multiple methods that evaluate causality: Bradford Hills Criteria to understand a causal relationship in epidemiological studies, mediation analysis, and Mendelian Randomization. MethodsIn 28,404 participants of European descent from ...

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