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GABA, glucose and insulin orchestrate CD4+ T cells effector functions

Jin, Z.; Hammoud, H.; Bhandage, A. K.; Korol, S. V.; Trujeque-Ramos, O.; Koreli, S.; Chowdhury, A. I.; Sandbaumhuter, F. A.; Jansson, E.; Bergstein, P.; Andren, P.; Kamali-Moghaddam, M.; Birnir, B.

2023-04-20 physiology
10.1101/2023.04.18.537327 bioRxiv
Show abstract

Metabolic programs of immune cells are closely linked to their effector functions. Physiological molecules including glucose, insulin and {gamma}-aminobutyric acid (GABA) provide environmental cues and guidance, although how they coordinate to regulate the cells is still being unraveled. Here, we demonstrate that GABA-mediated reduction of metabolic activity and release of inflammatory molecules, including IFN{gamma} and IL-10, was abolished in human CD4+ T cells when the glucose concentration was elevated above normal levels. Insulin enhanced the GABAA receptors-mediated currents and Ca2+ influx. GABA decreased, whereas insulin sustained glycolysis but in a SGLT (Na+-glucose transporter)-dependent manner. In high glucose (16.7 mM), the SGLTs antagonist phlorizin alone or together with GABA restored the inhibition of IFN{gamma} and IL-10 release. This study exposes concerted effects of GABA, glucose and insulin on CD4+ T cells metabolic activity and release of inflammatory molecules, and identifies a role for SGLTs in CD4+ T cells function.

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