Genome-wide association study stratified by MAPT haplotypes identifies potential novel loci in Parkinsons disease

2023-04-18 neurology Title + abstract only

Show abstract

ObjectiveTo identify genetic factors that may modify the effects of the MAPT locus in Parkinsons disease (PD). MethodsWe used data from the International Parkinsons Disease Genomics Consortium (IPDGC) and the UK biobank (UKBB). We stratified the IPDGC cohort for carriers of the H1/H1 genotype (PD patients n=8,492 and controls n=6,765) and carriers of the H2 haplotype (with either H1/H2 or H2/H2 genotypes, patients n=4,779 and controls n=4,849) to perform genome-wide association studies (GWASs)....