DRMY1 promotes robust morphogenesis by sustaining translation of a hormone signaling protein
Kong, S.; Zhu, M.; Scarpin, M. R.; Pan, D.; Jia, L.; Martinez, R. E.; Alamos, S.; Vadde, V. L.; Garcia, H. G.; Qian, S.-B.; Brunkard, J. O.; Roeder, A. H. K.
Show abstract
Robustness is the invariant development of phenotype despite environmental changes and genetic perturbations. In the Arabidopsis flower bud, four sepals robustly initiate and grow to constant size to enclose and protect the inner floral organs. We previously characterized the mutant development related myb-like1 (drmy1), where 3-5 sepals initiate variably and grow to different sizes, compromising their protective function. The molecular mechanism underlying this loss of robustness was unclear. Here, we show that drmy1 has reduced TARGET OF RAPAMYCIN (TOR) activity, ribosomal content, and translation. Translation reduction decreases the protein level of ARABIDOPSIS RESPONSE REGULATOR7 (ARR7) and ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN 6 (AHP6), two cytokinin signaling inhibitors that are normally rapidly produced before sepal initiation. The resultant upregulation of cytokinin signaling disrupts robust auxin patterning and sepal initiation. Our work shows that the homeostasis of translation, a ubiquitous cellular process, is crucial for the robust spatiotemporal patterning of organogenesis.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Spatial consistency of cell growth direction during organ morphogenesis requires CELLULOSE-SYNTHASE INTERACTIVE1 96%
- The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility 96%
- Optogenetic control of the Bicoid morphogen reveals fast and slow modes of gap gene regulation 95%
Similar papers in this journal
- The Arabidopsis SHORTROOT network coordinates shoot apical meristem development with auxin dependent lateral organ initiation 95%
- Imaging plant germline differentiation within Arabidopsis flower by light sheet microscopy 95%
- Competition between kinesin-1 and myosin-V define Drosophila posterior determination 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.