Allele pairing at Sun1-enriched domains at the nuclear periphery via T1A3 tandem DNA repeats
Balasooriya, G. I.; Spector, D. L.
Show abstract
Spatiotemporal gene regulation is fundamental to the biology of diploid cells. Therefore, effective communication between two alleles and their geometry in the nucleus is important. However, the mechanism that fine-tunes the expression from each of the two alleles of an autosome is enigmatic. By developing an allele-specific gene expression visualization system in living cells, we show that alleles of biallelically expressed Cth and Ttc4 genes are paired prior to acquiring monoallelic expression. We found that active alleles of monoallelic genes are preferentially localized at Sun1-enriched domains at the nuclear periphery. These peripherally localized euchromatic DNA loci harboring monoalleleic genes are enriched with adenine-thymidine-rich tandem repeats, which are bound by Hnrnpd, the "molecular wrench", to localize these loci in a Hi-C-defined A compartment within the B compartment. Our results demonstrate the biological significance of T1A3 tandem repeat sequences in genome organization and how the regulation of gene expression, at the level of individual alleles, relates to their spatial arrangement.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- SETDB1 Fuels the Lung Cancer Phenotype by Modulating Epigenome, 3D Genome Organization and Chromatin Mechanical Properties 97%
- Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity 96%
- The PIN1-p38-CtIP signaling axis protects stalled replication forks from deleterious degradation 96%
Similar papers in this journal
- Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops 97%
- SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state 97%
- Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons 97%
Similar papers in this journal
- ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination deficient cells 97%
- Polycomb sustains promoters in a deep OFF-state by limiting PIC formation to counteract transcription 96%
- The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.