Therapeutic interventions on human xenografts promote systemic dissemination of oncogenes
Raghuram, G. V.; Pal, K.; Sriram, G.; Khan, A.; Joshi, R.; Jadhav, V.; Shinde, S.; Sheikh, A.; Rane, B.; Kangne, H.; Mittra, I.
Show abstract
We generated xenografts of human cancer cells in mice, and using immuno-FISH analysis detected multiple co-localizing signals of human DNA and eight human oncoproteins in brain cells. Signals increased dramatically five days after treatment with chemotherapy, localized radiotherapy or surgery, which could be minimized by concurrent treatment with cell-free chromatin deactivating agents. These results suggest that therapeutic interventions may potentially encourage metastatic spread which is preventable by deactivating cell-free chromatin.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Radiation Induced Metabolic Alterations Associate with Tumor Aggressiveness and Poor Outcome in Glioblastoma 95%
- SPECT/CT imaging, biodistribution and radiation dosimetry of a 177Lu-DOTA-integrin αvβ6 cystine knot peptide in a pancreatic cancer xenograft model 94%
- mTOR inhibitors as radiosensitizers in neuroendocrine neoplasms 94%
Similar papers in this journal
- Modulating the unfolded protein response: Impacts of radiation on the response of prostate cancer cells to ONC201 94%
- Selective Impact of ALK and MELK Inhibition on ERα Stability and Cell Proliferation in Cell Lines Representing Distinct Molecular Phenotypes of Breast Cancer 94%
- Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases 93%
Similar papers in this journal
- GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors 95%
- The defined TLR3 agonist, Nexavant, exhibits anti-cancer efficacy and potentiates anti-PD-1 antibody therapy by enhancing immune cell infiltration. 95%
- A model of Zebrafish Avatar for co-clinical trials 94%
Similar papers in this journal
- High complexity cellular barcoding and clonal tracing reveals stochastic and deterministic parameters of radiation resistance 92%
- Adversary of DNA integrity: a long non-coding RNA stimulates driver oncogenic chromosomal rearrangement in human thyroid cells 92%
- Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration 92%
Similar papers in this journal
- Identification of novel exosomal miRNAs and their role in diagnosis and prognosis of Triple Negative Breast Cancer 93%
- NSMCE2, a Novel Super-Enhancer Regulated Gene, is Linked to Poor Prognosis and Therapy Resistance in Breast Cancer 93%
- Gene networks and expression quantitative trait loci associated with platinum-based chemotherapy response in high-grade serous ovarian cancer 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.