Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system
Peh, A.; Dinakis, E.; Nakai, M.; Muralitharan, R. R.; Rupasinghe, S.; Wilson, J. L.; Wong, C. H. Y.; Jama, H.; Barker, C. M. O.; Modarresi, M.; Kemp-Harper, B. K.; Zheng, T.; Marques, F. Z.; Broughton, B. R. S.
Show abstract
We provide evidence that stroke-induced gut breakdown results in bacteria translocation to the ischaemic mouse brain. Inhibition of sympathetic tone reduced bacterial load in the post-stroke brain and reduced functional deficits without altering cerebral apoptosis, neuroinflammation or infarct volume. These findings indicate that the activation of the sympathetic nervous system after stroke promotes gut-derived bacteria to enter to the brain, and this process worsens motor function in mice. Abstract Figure O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=106 SRC="FIGDIR/small/535309v1_ufig1.gif" ALT="Figure 1"> View larger version (32K): org.highwire.dtl.DTLVardef@1e78ca0org.highwire.dtl.DTLVardef@c1886forg.highwire.dtl.DTLVardef@1e45ae1org.highwire.dtl.DTLVardef@10aa224_HPS_FORMAT_FIGEXP M_FIG C_FIG
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