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A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut

Fogarty, E. C.; Schechter, M. S.; Lolans, K.; Sheahan, M. L.; Veseli, I.; Moore, R.; Kiefl, E.; Moody, T.; Rice, P. A.; Yu, M. K.; Mimee, M.; Chang, E. B.; McLellan, S. L.; Willis, A. D.; Comstock, L. E.; Eren, A. M.

2023-03-25 microbiology Community evaluation
10.1101/2023.03.25.534219 bioRxiv
Show abstract

Plasmids are extrachromosomal genetic elements that often encode fitness enhancing features. However, many bacteria carry cryptic plasmids that do not confer clear beneficial functions. We identified one such cryptic plasmid, pBI143, which is ubiquitous across industrialized gut microbiomes, and is 14 times as numerous as crAssphage, currently established as the most abundant genetic element in the human gut. The majority of mutations in pBI143 accumulate in specific positions across thousands of metagenomes, indicating strong purifying selection. pBI143 is monoclonal in most individuals, likely due to the priority effect of the version first acquired, often from ones mother. pBI143 can transfer between Bacteroidales and although it does not appear to impact bacterial host fitness in vivo, can transiently acquire additional genetic content. We identified important practical applications of pBI143, including its use in identifying human fecal contamination and its potential as an inexpensive alternative for detecting human colonic inflammatory states.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.