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Schrödinger's Cat in Simulations in Genome-wide Association Studies

Ozkaraca, M. I.; Tenesa, A.

2023-03-23 genomics
10.1101/2023.03.22.533184 bioRxiv
Show abstract

Simulations are essential components for testing methods or assumptions in genome-wide association studies (GWAS). We show through theory and examples that markers can be both causal and non-causal simultaneously, resulting in a paradox, had simulation not being run properly. We developed a software (ParaPheSim - a paradoxical phenotype simulator) that allows users to create different traits whose genetic correlation is exactly 1 and yet they have no genetic overlap.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.