Back

SARS-CoV-2 infection induces dopaminergic neuronal loss in midbrain organoids during short and prolonged cultures

Jarazo, J.; Santos da Silva, E.; Glaab, E.; Perez-Bercoff, D.; Schwamborn, J. C.

2023-03-21 neuroscience
10.1101/2023.03.20.533485 bioRxiv
Show abstract

COVID-19 is mainly associated with respiratory symptoms, although several reports showed that SARS-CoV-2 affects the nervous system. We evaluated the effects of infection in prolonged culture of midbrain organoids, showing that the virus induces changes in gene expression, and fragmentation and loss of dopaminergic neurons. Our findings highlight the direct viral-induced damage to midbrain organoids indicating the relevance of assessing the neurological long-term evolution of COVID-19 patients.

Matching journals

The top 8 journals account for 50% of the predicted probability mass.

1
Nature Communications
○ 5641 papers in training set
Top 9%
18.5%
Similar papers in this journal
2
Cell Death & Disease
147 papers in training set
Top 0.2%
6.7%
3
Communications Biology
○ 993 papers in training set
Top 2%
5.5%
Similar papers in this journal
4
iScience
○ 1154 papers in training set
Top 3%
4.9%
Similar papers in this journal
5
Cell Reports
○ 1498 papers in training set
Top 8%
4.9%
Similar papers in this journal
6
npj Parkinson's Disease
○ 105 papers in training set
Top 0.5%
4.3%
7
Scientific Reports
○ 3612 papers in training set
Top 22%
4.3%
8
Science Advances
● 1243 papers in training set
Top 8%
4.0%
50% of probability mass above
9
Nature Neuroscience
○ 252 papers in training set
Top 2%
3.2%
10
Cells
○ 249 papers in training set
Top 1%
3.2%
11
Molecular Psychiatry
○ 282 papers in training set
Top 2%
2.8%
12
EMBO Molecular Medicine
○ 95 papers in training set
Top 0.4%
2.4%
13
Cell Death Discovery
○ 58 papers in training set
Top 0.3%
2.4%
14
eLife
● 5828 papers in training set
Top 43%
2.4%
15
Cell Stem Cell
○ 62 papers in training set
Top 0.8%
1.9%
16
Nature Metabolism
○ 69 papers in training set
Top 1%
1.7%
17
Nature
○ 645 papers in training set
Top 7%
1.7%
18
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 28%
1.7%
19
Journal of Neuroinflammation
○ 61 papers in training set
Top 0.9%
1.3%
20
Current Biology
○ 665 papers in training set
Top 8%
1.1%
21
Neuron
○ 337 papers in training set
Top 4%
1.1%
22
The EMBO Journal
○ 309 papers in training set
Top 6%
0.8%
23
Cell Death & Differentiation
○ 48 papers in training set
Top 1%
0.8%
24
PLOS Biology
● 486 papers in training set
Top 11%
0.8%
25
EMBO Reports
○ 263 papers in training set
Top 7%
0.8%
26
Developmental Cell
○ 196 papers in training set
Top 5%
0.6%
27
Science
● 477 papers in training set
Top 10%
0.6%
28
Autophagy
○ 39 papers in training set
Top 0.7%
0.6%
29
Nature Biomedical Engineering
○ 47 papers in training set
Top 2%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.