Conditionally deleterious mutation load accumulates in genomic islands but can be purged with sufficient genotypic redundancy
Mee, J. A.; Carson, B.; Yeaman, S.
Show abstract
Local adaptation frequently evolves in patches or environments that are connected via migration. In these cases, genomic regions that are linked to an adaptive locus experience reduced effective migration rates. Via individual-based simulations of a two-patch system, we show that this reduced effective migration results in the accumulation of conditionally deleterious mutations, but not universally deleterious mutations, adjacent to adaptive loci. When there is redundancy in the genetic basis of local adaptation (i.e. genotypic redundancy), turnover of adaptive loci allows conditionally deleterious mutation load to be purged. The amount of mutational load that accumulates adjacent to adaptive loci is dependent on redundancy, recombination rate, migration rate, population size, strength of selection, and the phenotypic effect size of adaptive alleles. Our results highlight the need to be cautious when interpreting patterns of local adaptation at the level of phenotype or fitness, as the genetic basis of local adaptation can be transient, and evolution may confer a degree of maladaptation to non-local environments.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Impacts of pleiotropy and migration on repeated genetic adaptation 98%
- Polygenic adaptation to an environmental shift: temporal dynamics of variation under Gaussian stabilizing selection and additive effects on a single trait 97%
- The relative impact of evolving pleiotropy and mutational correlation on trait divergence 97%
Similar papers in this journal
Similar papers in this journal
- Host-pathogen coevolution promotes the evolution of general, broad-spectrum resistance and reduces foreign pathogen spillover risk 95%
- The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics 94%
- Experimental evolution confirms signatures of sexual selection in genomic divergence. 94%
Similar papers in this journal
- Interactions between natural selection and recombination shape the genomic landscape of introgression 97%
- Evolutionary Insights from a Large-scale Survey of Population-genomic Variation 95%
- The genomic architecture of adaptation to larval malnutrition points to a trade-off with adult starvation resistance in Drosophila 95%
Similar papers in this journal
- Polygenic selection to a changing optimum under self-fertilisation 97%
- The distribution of fitness effects during adaptive walks using a simple genetic network 96%
- Imbalanced segregation of recombinant haplotypes in hybrid populations reveals inter- and intrachromosomal Dobzhansky-Muller incompatibilities 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.