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ADCC-activating antibodies correlate with protection against congenital human cytomegalovirus infection
2023-03-17
infectious diseases
Title + abstract only
View on medRxiv
Show abstract
Human cytomegalovirus (HCMV) is the most common vertically transmitted infection worldwide, yet there are no licensed vaccines or therapeutics to prevent congenital HCMV (cCMV) infection. Emerging evidence from studies of natural infection and HCMV vaccine trials indicates that antibody Fc effector functions may defend against HCMV infection. We previously reported that antibody-dependent cellular phagocytosis (ADCP) and IgG activation of Fc{gamma}RI/Fc{gamma}RII were associated with reduced ris...
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