Downregulation of ribosomal RNA (rRNA) genes in human head and neck squamous cell carcinoma (HNSCC) cells is linked to rDNA promoter hypermethylation
Priyadarshini, N.; Puppala, N. V.; Jayaprakash, J. P.; Khandelia, P.; Sharma, V.; Mohannath, G.
Show abstract
Eukaryotes carry hundreds of ribosomal RNA (rRNA) genes as tandem arrays, which generate rRNA for protein synthesis. Humans carry ~ 400 rRNA gene copies, which are epigenetically regulated. Dysregulation of rRNA synthesis and ribosome biogenesis are characteristic features of cancers. Targeting aberrant rRNA expression for cancer therapy is being explored. Head and neck squamous cell carcinoma (HNSCC) is among the most prevalent cancers globally. Using quantitative PCR and bisulfite sequencing, we show that rRNA genes are downregulated and their promoters are hypermethylated in HNSCC cell lines. These finding may have relevance for prognosis and diagnosis for HNSCC.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Mitochondrial DNA is a sensitive surrogate and oxidative stress target in oral cancer cells 94%
- Methylation pattern of polymorphically imprinted nc886 is not conserved across mammalia 94%
- Identification of differential hypothalamic DNA methylation and gene expression associated with sexual partner preferences in rams 93%
Similar papers in this journal
- Oleic acid-related anti-inflammatory effects in force-stressed PdL fibroblasts are mediated by H3 lysine acetylation associated with altered IL10 expression 92%
- Dynamic chromatin accessibility landscape changes following interleukin-1 stimulation 91%
- Whole human genome 5'-mC methylation analysis using long read nanopore sequencing 91%
Similar papers in this journal
- DNA methylation in the upstream CpG island of the GPER locus and its relationship with GPER expression in colon cancer cell lines 92%
- Transcription factors involved in stem cell maintenance are downstream of Slug/Snail2 and repressed by TGF-β in bronchial basal stem/progenitor cells from COPD 92%
- A protocol for good quality genomic DNA isolation from formalin-fixed paraffin-embedded tissues without using commercial kits 92%
Similar papers in this journal
- Proteomics reveals how the tardigrade damage suppressor protein teaches transfected human cells to survive UV-C stress 93%
- Unveiling epigenetic regulatory elements associated with breast cancer development 93%
- Regulation Network of Colorectal Cancer Specific Enhancers in Progression of Colorectal Cancer 93%
Similar papers in this journal
- METTL3 alters capping enzyme expression and its activity on ribosomal proteins 94%
- A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution 93%
- Arsenic hexoxide has differential effects on cell proliferation and genome-wide gene expression in human primary mammary epithelial and MCF7 cells 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.