Quantitative Nanohistology of aging dermal collagen
Strange, A.; Maeva, A.; Huang, S.; Siddiqui, S.; Bastien, P.; Aguayo, S.; Vaez, M.; Pollock, H.; Ghibaudo, M.; Potter, A.; Pageon, H.; Bozec, L.
Show abstract
While the external signs of skin aging have been well-defined throughout history, much less is known about aging within the ultrastructure of our skin. Our skin, the largest organ in our body, is structured by collagen through fibrils or large sheets. With the increased use of nanometrology tools in histology, it is now possible to explore how the aging process affects collagen at its most fundamental level, the collagen fibril. Here, we show how atomic force microscopy-based quantitative nanohistology can differentiate skin from different age groups and anatomical sites. Following the definition of specific collagen biomarkers at the nanoscale, we used a segmentation approach to quantify the prevalence of 4 structural biomarkers over a dataset of 42,000 images (30 donors) complemented by extensive nanomechanical analyses (30,000 indentation curves) on histological sections. Our results demonstrate that specific age-related collagen fingerprints could be found when comparing the % prevalence of each marker between the papillary and reticular dermis. A case of abnormal biological aging validated our markers and nanohistology approach. This first extensive study focusing on defining signs of dermal aging at the nanoscale proves we are all unique to our dermal collagen ultrastructure.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Modulation of the Biophysical and Biochemical Properties of Collagen by Glycation for Tissue Engineering Applications 94%
- Three dimensional fibrotic extracellular matrix directs microenvironment fiber remodeling by fibroblasts 92%
- Biomaterial-based 3D human lung models replicate pathological characteristics of early pulmonary fibrosis 92%
Similar papers in this journal
- Tuning the Mechanical Properties and Printability of Viscoelastic Skin-Derived Hydrogels for 3D Cell Culture 92%
- Does mechanobiology drive respiratory disease? Biomechanical induction of mucus hypersecretion in human bronchial organoids using a photocontrolled biomaterial gel 91%
- Development of novel apoptosis-assisted lung tissue decellularization methods 91%
Similar papers in this journal
Similar papers in this journal
- A Glance into the Density of Transcriptomic Activity, Embodied by the HOX Genes, in Neonatal and Aging Dermal Cells 93%
- Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue 90%
- Behavior of Neural Cells Post Manufacturing and After Prolonged Encapsulation within Conductive Graphene-Laden Alginate Microfibers 89%
Similar papers in this journal
- Transcriptomic Analysis of Human Skin Wound Healing and Rejuvenation Following Ablative Fractional Laser Treatment 93%
- Skin aging risk factors: A nationwide population study in Mongolia 92%
- Neryl acetate, the major component of Corsican Helichrysum Italicum essential oil, mediates its biological activities on skin barrier 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.