Pilot proof for RNA biomarker-based minimally invasive endometrial receptivity testing using uterine fluid extracellular vesicles
Meltsov, A.; Giacomini, E.; Vigano, P.; Zarovni, N.; Salumets, A.; Aleksejeva, E.
Show abstract
Research questionHow accurate is minimally invasive assessment of endometrial receptivity from uterine fluid extracellular vesicles (UF-EVs) using only 68 RNA biomarkers. Study designAssessment of endometrial receptivity by applying the beREADY computational model on transcriptomic data derived from UF-EVs during the pre-receptive (LH+2) and receptive phases (LH+7) of a natural cycle. ResultsbeREADY housekeeping gene transcript levels in UF-EV are not significantly different between LH+2 and LH+7 UF-EVs. Endometrial receptivity can be assessed from UF-EV transcriptomic data using beREADY computational model with specificity of 100% and sensitivity of 75%. ConclusionbeREADY computational model can be used on UF-EVs instead of endometrial tissue biopsy to assess endometrial receptivity. However, further development is needed to fine-tune the model to show that this model can also be used on UF-EV samples from women undergoing hormone-replacement therapy.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Stratifying IVF population endometria using a prognosis gradient independent of endometrial timing. 97%
- Ovarian follicular function is not altered by SARS-Cov-2 infection or BNT162b2 mRNA Covid-19 vaccination 96%
- Human induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation 94%
Similar papers in this journal
Similar papers in this journal
- Validation of an in vitro diagnostic test for endometriosis: impact of confounding medical conditions and lesion location 95%
- Placental transcription profiling in 6-23 weeks’ gestation reveals differential transcript usage in early development 91%
- Does the rainbow trout ovarian fluid guide the spermatozoon on its way to the egg? 91%
Similar papers in this journal
- SoK: Intelligent Detection for Polycystic Ovary Syndrome(PCOS) 93%
- Blood biomarkers representing maternal-fetal interface tissues used to predict early-and late-onset preeclampsia but not COVID-19 infection 92%
- Risks and etiology of bacterial vaginosis revealed by species dominance network analysis 88%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.