Cerebrospinal fluid 2-hydroxyglutarate (2-HG) as a monitoring biomarker for IDH-mutant gliomas
Riviere-cazaux, C.; Lacey, J. M.; Carlstrom, L. P.; Laxen, W. J.; Munoz-Casabella, A.; Hoplin, M. D.; Ikram, S.; Bin Zubair, A.; Andersen, K. M.; Warrington, A. E.; Decker, P. A.; Kaufmann, T. J.; Campian, J. L.; Eckel-Passow, J. E.; Kizilbash, S. H.; Tortorelli, S.; Burns, T. C.
Show abstract
D-2-hydroxyglutarate (D-2-HG) is a well-established oncometabolite of isocitrate dehydrogenase (IDH) mutant gliomas. While prior studies have demonstrated that D-2-HG is elevated in the cerebrospinal fluid (CSF) of patients with IDH-mutant gliomas1,2, no study has determined if CSF D-2-HG can provide a plausible method to evaluate therapeutic response. We are obtaining CSF samples from consenting patients during their disease course via intra-operative collection and Ommaya reservoirs. D-2-HG and D/L-2-HG consistently decreased following tumor resection and throughout chemoradiation in patients monitored longitudinally. Our early experience with this strategy demonstrates the potential for intracranial CSF D-2-HG as a monitoring biomarker for IDH-mutant gliomas.
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