Dentate neurogenesis mediates cognitive flexibility via modulation of the hippocampal longitudinal-axis network
Li, H.; Tamura, R.; Hayashi, D.; Asai, H.; Koga, J.; Ando, S.; Yokota, S.; Kaneko, J.; Sakurai, K.; Sumiyoshi, A.; Yamamoto, T.; Hikishima, K.; Tanaka, K. Z.; McHugh, T.; Hisatsune, T.
Show abstract
Adult neurogenesis endows the hippocampus with unparalleled neural plasticity, essential for intricate cognitive functions. However, the manner in which sparse newborn neurons (NBNs) modulate neural activities and subsequently shape behavior remains enigmatic. Utilizing a newly engineered NBN-Tetanus Toxin mouse model, we non-invasively silenced NBNs and confirmed their crucial role in cognitive flexibility, as demonstrated through reversal learning in the Morris water maze and the Go/Nogo task in operant learning. Pairing task-based functional MRI (tb-fMRI) with operant learning revealed a dorsal hippocampal hyperactivation during Nogo task, implying that hippocampal hyperexcitability might underlie the observed behavioral deficits. Notably, resting-state fMRI (rs-fMRI) revealed enhanced functional connectivity between the dorsal and ventral dentate gyrus following NBN silencing. Further exploration of PV+ interneurons and mossy cells activities highlighted NBNs integral part in preserving the excitation/inhibition balance within the hippocampus. Our findings emphasize how the neural plasticity driven by NBNs extensively modulates the hippocampus, sculpting cognitive flexibility.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Acquisition of Auditory Discrimination Mediated by Different Processes through Two Distinct Circuits Linked to the Lateral Striatum 96%
- KIF2C regulates synaptic plasticity and cognition by mediating dynamic microtubule invasion of dendritic spines 95%
- MicroRNA-218 instructs proper assembly of hippocampal networks 95%
Similar papers in this journal
- KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors 95%
- Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors 95%
- Prefrontal gamma oscillations and fear extinction learning require early postnatal interneuron-oligodendroglia communication 95%
Similar papers in this journal
- A simple and reliable method for claustrum localization across age in mice 93%
- Outer layer of Vb neurons in medial entorhinal cortex project to hippocampal dentate gyrus in mice 92%
- Conditional Pten knockout in parvalbumin- or somatostatin-positive neurons sufficiently leads to autism-related behavioral phenotypes 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.