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Hidden changes to prespecified primary outcomes of clinical trials completed between 2009 and 2017 in German University Medical Centres: A meta-research study
2023-02-21
medical ethics
Title + abstract only
View on medRxiv
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ObjectivesTo assess how often clinical trials exhibit primary outcome discrepancies within registry records that would not be caught by comparing results publications to the latest registry entry, but would require analysing the registration history. DesignMeta-research study. SettingAll 1746 randomised clinical trials with published results, registered in ClinicalTrials.gov or Deutsches Register Klinischer Studien (DRKS), completed at German University Medical Centres between 2009 and 2017. W...
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