Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
Liu, D.; Silva, F. A. M.; Sanatkhani, S.; Pouliopoulos, A.; Konofagou, E.; Grinband, J.; Ferrera, V. P.
Show abstract
Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and compared changes in functional connectivity in major brain networks. We found different alteration patterns between FUS neuromodulation and FUS-mediated BBB opening in several cortical areas, and we also found that applying FUS to a deep brain structure can alter functional connectivity in the default mode network and frontotemporal network.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Alteration of Water Exchange Rates Following Focused Ultrasound-Mediated BBB Opening in the Dorsal Striatum of Non-Human Primates: A Diffusion-Prepared pCASL Study 95%
- Effects of tDCS Dose and Electrode Montage on regional cerebral blood flow and motor behavior 92%
- Zero-echo time imaging achieves whole brain activity mapping without ventral signal loss in mice 92%
Similar papers in this journal
- Functional Connectivity Evoked by Orofacial Tactile Perception of Velocity 92%
- Decoding Neural Activity in Sulcal and White Matter Areas of the Brain to Accurately Predict Individual Finger Movement and Tactile Stimuli of the Human Hand 91%
- High Gamma and Beta Temporal Interference Stimulation in the Human Motor Cortex Improves Motor Functions 90%
Similar papers in this journal
- Group and Individual Level Variations between Symmetric and Asymmetric DLPFC Montages for tDCS over Large Scale Brain Network Nodes 93%
- Real Time and Delayed Effects of Subcortical Low Intensity Focused Ultrasound 93%
- Multivariate pattern classification on BOLD activation pattern induced by deep brain stimulation in motor, associative, and limbic brain networks 92%
Similar papers in this journal
Similar papers in this journal
- Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control 94%
- Small volume blood-brain barrier opening in macaques with a 1 MHz ultrasound phased array 93%
- Enhanced capillary delivery with nanobubble-mediated blood-brain barrier opening and advanced high resolution vascular segmentation 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.