The Development of Synapses in Mouse and Macaque Primary Sensory Cortices
Wildenberg, G. A.; Li, H.; Kasthuri, N.
Show abstract
We report that the rate of synapse development in primary sensory cortices of mice and macaques is unrelated to lifespan, as was previously thought. We analyzed 28,084 synapses over multiple developmental time points in both species and find, instead, that net excitatory synapse development of mouse and macaque neurons primarily increased at similar rates in the first few postnatal months, and then decreased over a span of 1-1.5 years of age. The development of inhibitory synapses differed qualitatively across species. In macaques, net inhibitory synapses first increase and then decrease on excitatory soma at similar ages as excitatory synapses. In mice, however, such synapses are added throughout life. These findings contradict the long-held belief that the cycle of synapse formation and pruning occurs earlier in shorter-lived animals. Instead, our results suggest more nuanced rules, with the development of different types of synapses following different timing rules or different trajectories across species.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner 94%
- Laminar-specific cortico-cortical loops in mouse visual cortex 94%
- Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell 94%
Similar papers in this journal
- Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals 96%
- Interhemispheric connections between olfactory bulbs improve odor detection 93%
- The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages 93%
Similar papers in this journal
- Cell-type Specific Learning of Attentional Gating in Primate Striatum 94%
- All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity 94%
- Reciprocal interaction between cortical SST and PV interneurons in regulating top-down retinothalamic refinement 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.