Mortality and Mode of Dialysis. Meta-Analysis and Systematic Review

BackgroundDialysis is an intervention used chiefly to cover poorly functioning kidneys ultrafiltration and diffusion functions. Dialysis can be performed using three major approaches: peritoneal dialysis, hemodialysis, and continuous renal replacement therapy, which have varying degrees of efficiency. We sought to compare the mortality rates among patients receiving different dialysis modalities. Study DesignStatistical Review and Meta-Analysis. Setting & PopulationThe investigation was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Data sources were drawn from Google Scholar, ResearchGate, PubMed (MEDLINE), Cochrane Library, and Embase databases. Eligible patients had to be ones presenting with acute or chronic kidney failure who required assistance with kidney function. Selection Criteria for StudiesThe eligibility criteria included studies with participants requiring dialysis and comparing two of the three dialysis modalities that provided outcomes on mortality rates. Inclusion criteria (underlying disease, chronic or acute kidney disease, presenting signs, age categories, subject consent, etc.), the type of dialysis modalities under investigation, and the mortality rates (% per modality group). Index Texts mortalities, fatalities, dialysis, hemodialysis, continuous renal replacement therapy (CRRT), Peritoneal dialysis, and comparative. OutcomesWe sought to explore the studies findings by comparing the mortality rates among the three broad categories of dialysis. Therefore, we aimed to compare mortality rates in CRRT vs. Hemodialysis, mortality Rates in CRRT vs. PD, and mortality rates in patients with PD vs. HD. ResultsFifteen studies were narrowed down from the study search and were placed into three categories: PD vs. CRRT (4), PD vs. HD (5), and CRRT vs. HD (6). For the three outcomes, none recorded statistically significant differences in mortality rates between the patient categories (p= 0.92, 0.009, 0.22). ConclusionLike other interventions for patients with chronic kidney disease, dialysis is associated with detrimental effects caused by the inflammatory response and worsening progression of the condition. Mortality is a common complication among dialysis patients, independent of modality, based on the lack of statistically significant differences between the three groups.