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Prebiotic activity of lactulose optimizes gut metabolites and prevents systemic infection in liver disease patients

2023-02-16 gastroenterology Title + abstract only
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Progression of chronic liver diseases is precipitated by hepatocyte loss, inflammation and fibrosis. This process results in the loss of critical hepatic functions, increasing morbidity and the risk of infection. Medical interventions that treat complications of hepatic failure, including antibiotic administration for systemic infections, impact gut microbiome composition and metabolite production. Using a multi-omics approach on 850 fecal samples from 263 patients with acute or chronic liver di...

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