Integrative single-cell characterization of frugivory adaptations in the bat kidney and pancreas
Gordon, W. E.; Baek, S.; Nguyen, H. P.; Kuo, Y.-M.; Bradley, R.; Galazyuk, A.; Lee, I.; Ingala, M.; Simmons, N. B.; Schountz, T.; Cooper, L.; Georgakopoulos-Soares, I.; Hemberg, M.; Ahituv, N.
Show abstract
Frugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely unknown. Here, we used integrative single-cell sequencing on insectivorous and frugivorous bat kidneys and pancreases and identified key cell population, gene expression and regulatory element differences associated with frugivorous adaptation that also relate to human disease, particularly diabetes. We found an increase in collecting duct cells and differentially active genes and regulatory elements involved in fluid and electrolyte balance in the frugivore kidney. In the frugivorous pancreas, we observed an increase in endocrine and a decrease in exocrine cells and differences in genes and regulatory elements involved in insulin regulation. Combined, our work provides novel insights into frugivorous adaptation that also could be leveraged for therapeutic purposes.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The evolution of ecological flexibility, large brains, and long lives: capuchin monkey genomics revealed with fecalFACS 94%
- Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury 94%
- Evolutionary and Developmental Specialization of Foveal Cell Types in the Marmoset 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.