Subdural CMOS optical probe (SCOPe) for bidirectional neural interfacing
Pollmann, E. H.; Yin, H.; Uguz, I.; Dubey, A.; Wingel, K. E.; Choi, J. S.; Moazeni, S.; Gilhotra, Y.; Pavlovsky, V. A.; Banees, A. A.; Boominathan, V.; Robinson, J.; Veeraraghavan, A.; Pieribone, V. A.; Pesaran, B.; Shepard, K. L.
Show abstract
Optical neurotechnologies use light to interface with neurons and can monitor and manipulate neural activity with high spatial-temporal precision over large cortical extents. While there has been significant progress in miniaturizing microscope for head-mounted configurations, these existing devices are still very bulky and could never be fully implanted. Any viable translation of these technologies to human use will require a much more noninvasive, fully implantable form factor. Here, we leverage advances in microelectronics and heterogeneous optoelectronic packaging to develop a transformative, ultrathin, miniaturized device for bidirectional optical stimulation and recording: the subdural CMOS Optical Probe (SCOPe). By being thin enough to lie entirely within the subdural space of the primate brain, SCOPe defines a path for the eventual human translation of a new generation of brain-machine interfaces based on light.
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