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A thin-film optogenetic visual prosthesis

Knudsen, E. B.; Zappitelli, K.; Brown, J.; Reeder, J.; Smith, K. S.; Rostov, M.; Choi, J.; Rochford, A.; Slager, N.; Miura, S. K.; Rodgers, K.; Reed, A.; Lewis Israeli, Y. R.; Shiraga, S.; Seo, K. J.; Wolin, C.; Dawson, P.; Eltaeb, M.; Dasgupta, A.; Chong, P.; Charles, S.; Stewart, J. M.; Silva, R. A.; Kim, T.; Kong, Y.; Mardinly, A. R.; Hodak, M.

2023-02-03 neuroscience Community evaluation
10.1101/2023.01.31.526482 bioRxiv
Show abstract

Retinitis pigmentosa and macular degeneration lead to photoreceptor death and loss of visual perception. Despite recent progress, restorative technologies for photoreceptor degeneration remain largely unavailable. Here, we describe a novel optogenetic visual prosthesis (FlexLED) based on a combination of a thin-film retinal display and optogenetic activation of retinal ganglion cells (RGCs). The FlexLED implant is a 30 {micro}m thin, flexible, wireless {micro}LED display with 8,192 pixels, each with an emission area of 66 {micro}m2. The display is affixed to the retinal surface, and the electronics package is mounted under the conjunctiva in the form factor of a conventional glaucoma drainage implant. In a rabbit model of photoreceptor degeneration, optical stimulation of the retina using the FlexLED elicits activity in visual cortex. This technology is readily scalable to hundreds of thousands of pixels, providing a route towards an implantable optogenetic visual prosthesis capable of generating vision by stimulating RGCs at near-cellular resolution.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.