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Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life
2023-01-31
infectious diseases
Title + abstract only
View on medRxiv
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The dynamics of innate and adaptive immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to SARS-CoV-2 infection in infants and young children in the first weeks and months of life by analyzing blood samples collected before, during, and after infection with Omicron and Non-Omicron variants. Infection stimulated robust antibody titers that, unlike in adults, were stably maintained for >300 days. Antigen-specific memo...
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