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No compliment for complement: Kidney biopsies of patients with malignant nephrosclerosis show no complement activation

2023-01-29 nephrology Title + abstract only
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The complement system represents an ancient part of innate immunity and is comprised of multiple serum proteins. In several pathological conditions, including atypical hemolytic syndrome (aHUS), complement activation is contributing to disease progression. Therefore, pharmacological targeting of complement is a viable therapeutic strategy in this population. Recent data suggest complement activation in patients suffering from malignant hypertension and stenosing arteriosclerosis also called mal...

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