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Disrupted trans-placental thyroid hormone transport in a human model for MCT8 deficiency

Chen, Z.; Leeuwenburgh, S.; Zijderveld, W. F.; Broekhuizen, M.; Tan, L.; Neuman, R. I.; Jongejan, R. M. S.; de Rijke, Y. B.; Reiss, I. K. M.; Danser, A. H. J.; Peeters, R. P.; Meima, M. E.; Visser, W. E.

2023-01-20 pathology
10.1101/2023.01.19.524727 bioRxiv
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Introduction ABSTRACT Introduction Results Discussion Materials and methods Author contributions Conflict of interest statement The Paper Explained Problem Results Impact Expanded View Figures References Thyroid hormones, the collective name for the prohormone T4 and the active hormone T3, are crucial for neurodevelopment. During prenatal neurodevelopment, maternal-to-fetal T4 transfer is critical, particularly during the first half of pregnancy with the fetal thyroid gland being immature (Patel et al, 2011). Therefore, maternal thyroid dysfunction negatively impacts brain structure and function in the offspring (Jansen et al, 2019; ...

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